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Do the TSKgel PW/PWXL columns shed microparticles?

PostPosted: Wed 29 Jun 2016 13:42
by Interchim
Do the TSKgel PW/PWXL columns shed microparticles?
FAQ from TOSOH

Microparticles do not interfere with most detection methods used in HPLC. However, these particles can increase the noise level in laser light scattering detection systems. To minimize this effect using the PW/PWXL columns run the column overnight in 10-20% methanol at one-half the normal flow rate to clean any microparticles off the resin.