TransSilent™ TF siRNA Vectors

Achieve effective gene knockdown with TranSilent TF siRNA vectors

  • Specific - siRNA vectors target TF mRNA sequences

  • Easy to use - only transfection required

  • Effective - functionally tested to reduce gene expression by 80-90%

  • Long-lasting - stable vector-expression of siRNA

  • Flexible - clone your own insert into our control siRNA vector

  • Verifiable - optional TF antibodies for each siRNA

Figure 1: Schematic Diagram of the RNA interference mechanism.

After being processed in the cell, the vector-expressed siRNA is incorporated into a multi-protein nuclease complex known as the RNA-induced silencing complex (RISC). Homology between the sense portion of the siRNA sequence and the mRNA enables the nuclease enzyme to bind and cleave the TF-encoding transcript into small pieces, which are degraded by the cell’s machinery. Once the cleavage of one mRNA molecule has occurred, the RISC is freed from the transcript to perform additional rounds of catalysis.

Panomics currently offer TranSilent siRNA vectors that target 46 different TFs.

Each vector can be purchased with or without antibody to the corresponding TF. 

INTERCHIM DNA Microarray

Microarray and gene expression studies

Slides and Reagents for self-printing microarrays

Hybridization

Calibration & Software

Complementary Studies

 

 

TranSilent siRNA

Catalog #

TF Full Name

AR

SR1007

Androgen receptor

ATF1

SR1008

Activating transcription factor 1

ATF4

SR1009

Activating transcription factor 4 (ATF4)

c-Myb

SR1002

c-myb proto-oncogene product

CREB1

SR1010

cAMP-responsive element binding protein 1

E47

SR1011

E2A immunoglobulin enhancer binding factors E12/E47

EGR1

SR1012

Early growth response 1

ELK1

SR1013

ELK1, member of the ETS oncogene family

ERα

SR1014

Estrogen receptor 1 (alpha)

ERβ

SR1015

Estrogen receptor-beta

E2F1

SR1016

E2F1 transcription factor

E2F2

SR1017

E2F2 transcription factor

E2F3

SR1018

E2F3 transcription factor

Ets1

SR1019

v-Ets erythroblastosis virus E26 oncogene homologue 1

Fos

SR1001

v-Fos FBJ murine osteosarcoma viral oncogene homologue

FosB

SR1020

FBJ murine osteosarcoma viral oncogene homologue B

GATA1

SR1021

GATA binding protein 1 (globin transcription factor 1)

GATA2

SR1022

GATA binding protein 2

GATA3

SR1023

GATA binding protein 3

GRα

SR1003

NR3C1: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

HNF4

SR1024

Hepatocyte nuclear factor 4, alpha

IRF1

SR1025

Interferon regulatory factor

JUN

SR1026

v-Jun sarcoma virus 17 oncogene homologue (avian)

JUNB

SR1027

JunB proto-oncogene

JUND

SR1028

JunD proto-oncogene

MADH1

SR1029

Drosophila Mad and C. elegans Sma genes

MADH2

SR1030

MAD, mothers against decapentaplegic homologue 2 (Drosophila)

MADH3

SR1031

MAD, mothers against decapentaplegic homologue 3 (Drosophila)

Max

SR1032

MAX protein

NFκB50

SR1033

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

NFκB65

SR1005

v-Rel reticuloendotheliosis viral oncogene homologue A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)

p53

SR1004

Tumour protein p53

PPARA

SR1006

Peroxisome proliferative activated receptor, alpha

PPARD

SR1034

Peroxisome proliferative activated receptor, delta

RXRA

SR1035

Retinoid X receptor, alpha

RXRB

SR1036

Retinoid X receptor, beta

SP1

SR1037

Sp1 transcription factor

SRF

SR1038

Serum response factor (c-fos serum response element-binding transcription factor)

Stat1

SR1039

Signal transducer and activator of transcription 1, 91kD

Stat2

SR1040

Signal transducer and activator of transcription 2, 113kD

Stat3

SR1041

STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)

Stat6

SR1042

Signal transducer and activator of transcription 6, interleukin-4 induced

TP73

SR1043

Tumour protein p73

TRα

SR1044

Thyroid hormone receptor, alpha (THRA)

VDR

SR1045

Vitamin D (1,25- dihydroxyvitamin D3) receptor

YY1

SR1046

YY1 transcription factor

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