Autophagy is a cellular self-digestion process central to development, aging, immunity and cell death. This process is important to maintain a well-controlled balance between anabolism and catabolism in order to have normal cell growth and development. It plays an essential role during starvation, cellular differentiation, cell death, and in preventing some types of cancer. This degradation pathway permits the cell to eliminate unwanted or unnecessary organelles and to recycle the components for reuse.
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Figure 1: Autophagy APG8a (MAP1LC3A) Antibody (N-term) Western blot analysis of anti-APG8a Pab (Cat. No. BY9270) in rat brain lysate. Both cleaved (arrow II) and non-cleaved APG8a (arrow I) were detected in membrane fraction (P) whereas only non-cleaved APG8a was detected in soluble fraction (S). Immunofluorescence data is kindly provided by Dr. Susan Cotman from the Massachusetts General Hospital (Boston, MA). |
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Figure 2: Autophagy APG8b (MAP1LC3b) Antibody
(N-term) Immunofluorescence analysis of anti-APG8b Pab (Cat. No. BY9280) before
(left) and after (right) treatment with rapamycin (100 nM for 4 hr). Data is kindly provided by Dr. Susan Cotman from the Massachusetts General Hospital (Boston, MA).
