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INTERFINE CHEMICALS > Chemicals > Chemistry Kits > Photochemical Reactions

Photochemical methylation

Example :

Photochemical_Methylation_Hepatochem_Interchim_0817
 
# HCK1009-01-001

  [Ir{dF(CF3)ppy}2(dtbbpy)]PF6 [Ir(ppy)2(dtbbpy)]PF6
50/50 Acetonitrile/TFA 5 equiv. tert-butyl peracetic acid
Acetonitrile (10 equiv. TFA)
Acetic acid (10 equiv. TFA)
Acetic acid/H2O (10 equiv. TFA)


Cross Coupling reactions Iridium/Nickel Photoredox Kits
 

 
Product overview:
In recent years photoredox chemistry has become a powerful tool for chemical synthesis. Many reaction conditions have been reported in the literature using a wide range of catalysts and reagents.
However, often these reactions are highly substrate, solvent and base specific. In order to facilitate the screening of common photochemistry reactions, HepatoChem has released a series of kits combining common Iridium, Nickel, ligand and base combinations to achieve successful cross-coupling transformations.


Iridium_Nickel_Hepatochem_Interchim_1017 Ir/Ni catalysis versatility
Depending on the ligand, base and solvent, the Ir/Ni
catalytic systems can perform different types of
cross-coupling reaction.

C-C coupling
Example :

C-C_Coupling_IrNi_Hepatochem_Interchim_0817
 
 C-N coupling
Example :

C-N_Coupling_IrNi_Hepatochem_Interchim_0817
 
Iridium catalyst
Ir(dF-CF3-ppy)2(dtbpy)PF
6

Iridium_Catalyst_Hepatochem_Interchim_0817
 
Nickel Ligands

dtbbpy_Hepatochem_Interchim_0817 MeO2bpy_Hepatochem_Interchim_0817
dtbbpy

(MeO)2bpy

bphen_Hepatochem_Interchim_0817 biox_Hepatochem_Interchim_0817
bphen biox

 

Ir/Ni base and solvent screen kit 1

With Iridium catalyst Ir(dF-CF3-ppy)2(dtbbpy)PF6 and Ni ligand dtbbpy

  Cs2CO3 K3PO4 K2HPO4 KOH Li2CO3 K2CO3 DABCO DBU
Solvent A 2 sets of 8 bases per kit (16 total vials)
# HCK1009-01-002
Solvent B

 

Ir/Ni base and ligand screen kit 2 & 3

With Iridium catalyst Ir(dF-CF3-ppy)2(dtbbpy)[PF6]

  Cs2CO3 K3PO4 K2HPO4 K2CO3 PDABCO DBU
  2 sets of 4 bases and 4 ligands per kit
(32 total vials)
# HCK1009-01-003
2 sets of 6 bases and 4 ligands per kit
(48 total vials)
# HCK1009-01-004
 
 
 

 

Ir/Ni base and Ir catalyst screen kit 4

  Cs2CO3 CsF DBU  
Ir(dF-CF3-ppy)2(dtbbpy)PF6 2 sets of 3 bases and 6 Ir catalysts
per kit (36 total vials)
# HCK1009-01-005
With
Ni ligand dtbbpy
Ir(dtbbpy)(ppy)2PF6
Ir(dF-CF3-ppy)2(bpy)PF6
Ir(dF-ppy)3
Ir(dmppy)2(dtbbpy)PF6
Ir(dF-CH3-ppy)2(dtbbpy)PF6


Photocatalytic Alkylation Diversification Kit
 

 
Product overview: HCK1016-01-001
The trifluoroborate alkylation reaction (Minisci reaction) described by Prof. Molander is a powerful late stage functionalization tool. Our kit allows to conveniently produce in one step 8 different analogues of a lead compound in mg quantities. Each reaction vial contains 75 µmol of trifluoroborate alkylation reagent (pre-weighed) and a stirring bar to react with 50 µmol of substrate. C-H functionalization will primarily occur on electron-deficient heteroarenes at one or several positions.


8 Different Diversification Groups

Iridium_Nickel_Hepatochem_Interchim_1017
 
Kit contents HCK1016-01-001:2 reaction vials of each BF3K reagents (75 μmol) and K2S2O8 (100 μmol), 2 vials of photocatalysts and 2 vials of TFA, 16 reaction vials total.

 

Photocatalytic Alkylation Diversification Kit

Product overview
 

The trifluoroborate alkylation reaction (Minisci reaction) described by Prof. Molander is a powerful late stage functionalization tool. Hepatochem kit allows to conveniently produce in one step 8 different analogues of a lead compound in mg quantities. Each reaction vial contains 75 μmol of trifluoroborate alkylation reagent (pre-weighed) and a stirring bar to react with 50 μmol of substrate. C-H functionalization will primarily occur on electron-deficient heteroarenes at one or several positions.
 

8 Different Diversification Groups
 

Photocatalytic_alkylation_Interchim_0618
 
Kit contents HCK1016-01-001: 2 reaction vials of each BF3K reagents (75 μmol) and K2S2O8 (100 μmol), 2 vials of photocatalysts and 2 vials of TFA, 16 reaction vials total
 

Photocatalytic Alkylation Reagents (2 Vials of each)

    Potassium cyclopropyl trifluoroborate   Potassium cyclobutyl trifluoroborate   Potassium cyclopentyl trifluoroborate   Potassium cyclohexyl trifluoroborate   Potassium ethyl trifluoroborate   Potassium isopropyl trifluoroborate   Potassium methoxymethyl trifluoroborate   t-Butyl peracetate
    Potassium_cyclopropyl_trifluoroborate_Interchim_0618   Potassium_cyclobutyl_trifluoroborate_Interchim_0618   Potassium_cyclopentyl_trifluoroborate_Interchim_0618   Potassium_cyclohexyl_trifluoroborate_Interchim_0618   Potassium_ethyl_trifluoroborate_Interchim_0618   Potassium_isopropyl_trifluoroborate_Interchim_0618   Potassium_methoxymethyl_trifluoroborate_Interchim_0618   t-Butyl_peracetate_interchim_0618
MW (g/mol)   147.98   162.00   176.03   190.06   135.97   149.99   151.97   132.16
 
CAS Number   1065010-87-8   1065010-88-9   1040745-70-7   446065-11-8   44248-07-9   1041642-13-0   910251-11-5   107-71-1

 

Literature references:
Jennifer K. Matsui, David N. Primer and Gary A. Molander Chem. Sci., 2017,8, 3512-3522
Tim Cernak, Kevin D. Dykstra, Sriram Tyagarajan, Petr Vachal and Shane W. Krska Chem. Soc. Rev., 2016,45, 546-576.
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