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Hello,
I just bought a capillary column DB130MX0.32MMX3.00UM (123-1034).
Could you please tell me if this column is sensitive to the "normal" acid or isobutyric acid (different answer between two columns during the calibration) ?
Is it possible to inject on this column fluorinated products ?
I have noted, during the rise of T°C, a sinusoidal drift.
Could you please tell me if it is significant of a particular problem ? I have verified leaks, cleaned injector/detector.
Thanks

Hello,
To my mind, the only organic compounds that have been reported to damage stationary phases are perfluoroacids.
Examples include trifluoroacetic, pentafluoropropanoic, and heptafluorobutyric acid. They need to be present at high levels (e.g., 1% or higher).
Most of the problems are experienced with splitless or direct injections where large volumes of the sample are deposited at the front of the column.
Since chemical damage is usually limited to the front of the column, trimming or cutting 1/2-1 meter from the front of the column often eliminates any chromatographic problems.
Even more serious are oxygen damages caused by leaks and even worse at elevated temperatures.
By the time oxygen damage is discovered by increasing bleeding, significant column damage has already occurred.
In less severe cases, the column may still be functional but at a reduced performance level. In more severe cases, the column is irreversibly damaged.