The high purity of i-colloid Au
Posted: Thu 21 Jul 2016 11:10The high purity of i-colloid Au
I-colloid
Technical note T02
High purity matters.
Material purity is of crucial importance for biomedical applications. Although gold nanoparticles are generally considered nontoxic and biocompatible, impurities can be introduced during production process. Conventional chemical synthesis involves a variety of precursors, reducing agents, and stabilizers. Impurities present in a final product can include residual reactants, stabilizers, and preservatives. The high purity of IMRA’s i-colloid Au is made possible by a pulsed laser ablation process, in which a bulk gold is fragmented into nanoparticles by a focused high power pulsed laser beam, therefore ensuring a reactant-free and stabilizer-free production.
Purity characterization: elemental analysis
The following elemental concentrations are analyzed using high sensitivity analytical methods:
Purity characterization: electrical conductivity
Electrical conductivity (k) is a convenient and sensitive measurement that reflects the total ionic concentration of an electrolyte. The level of total dissolved solid (TDS) can be estimated following the relationship: 1 mS/cm of k represents approximately 0.7 ppm of TDS.
Table 1. Purity comparison between 20 nm i-colloid Au and other products (all in OD 1)
Fig. 1. Purity comparison between 20 nm i-colloid Au and other products (all in OD 1). (†: Below machine detection limit. Number assumed from Na concentration.)
I-colloid
Technical note T02
High purity matters.
Material purity is of crucial importance for biomedical applications. Although gold nanoparticles are generally considered nontoxic and biocompatible, impurities can be introduced during production process. Conventional chemical synthesis involves a variety of precursors, reducing agents, and stabilizers. Impurities present in a final product can include residual reactants, stabilizers, and preservatives. The high purity of IMRA’s i-colloid Au is made possible by a pulsed laser ablation process, in which a bulk gold is fragmented into nanoparticles by a focused high power pulsed laser beam, therefore ensuring a reactant-free and stabilizer-free production.
Purity characterization: elemental analysis
The following elemental concentrations are analyzed using high sensitivity analytical methods:
Purity characterization: electrical conductivity
Electrical conductivity (k) is a convenient and sensitive measurement that reflects the total ionic concentration of an electrolyte. The level of total dissolved solid (TDS) can be estimated following the relationship: 1 mS/cm of k represents approximately 0.7 ppm of TDS.
Table 1. Purity comparison between 20 nm i-colloid Au and other products (all in OD 1)
Fig. 1. Purity comparison between 20 nm i-colloid Au and other products (all in OD 1). (†: Below machine detection limit. Number assumed from Na concentration.)