What is Annexin V-FITC 4830-01-01?
FAQ from Trevigen
In normal cells, phosphatidylserine (PS) is sequestered along the inner surface of the cytoplasmic membrane. During apoptosis, PS redistributes along the outer surface of the membrane due to caspase inactivation of the PS flippase enzyme. Annexin V is a calcium-dependent phospholipid binding protein. Binding of FITC labeled Annexin V to PS provides a fluorescent detection format for PS externalization and is an indicator of apoptosis.