Topics of the month...

20% OFF Abgent autophagy antibodies

Autophagy is a catabolic trafficking pathway for bulk destruction/ turnover of long-lived proteins and organelles via regulated lysosomal degradaton. The process consists of sequential: signaling, sequestration of cytoplasm, formation of a unique double membrane vesicle (autophagosome), targeting of the completed vesicle to the lysosome/vacuole followed by docking and fusion, and breakdown. Autophagy occurs constitutively at low levels to perform housekeeping functions such as destruction of dysfunctional organelles, with dramatic upregulation in the presence of external stressors, and internal needs.

Autophagic proteins serve as key players via participation in the :

1) protein serine/threonine kinase complex that relays upstream signals from TOR kinase,
2) the lipid kinase signaling complex that engages vesicle nucleation,
3) the ubiquitin-like conjugation pathway that facilitates vesicle expansion, and
4) the recycling pathway for removal of autophagy proteins from autophagosomes.

• LC3 • p62 • APG4 • APG5 >• >APG12 • Beclin •See full antibody list