HPLC

 

Uptisphere, BioP I & BioP II for Bioanalysis

 

 

Analysis

 

BioP I and BioP II columns have been designed to fulfil the analytical demands of bioanalysis, a common requirement of pharmaceutical DMPK departments. The silica support of the BioP column has been adapted to accommodate the "cruder" samples often utilised in DMPK and the subsequent reduced extraction characteristics. BioP supports have unparalleled mechanical strength, displaying up to three times the shelf life of other manufacturers silica. The BioP I support is comparable to the Uptisphere C18-ODB support and is suited to analysis of moderately polar and non-polar compounds. BioPII is comparable to Uptisphere C18-HDO support, it has a better affinity for hydrophilic compounds and facilitates the use of an aqueous mobile phase. To optimise sample extraction, Interchim recommend the use of Upti-clean and Atoll sample.

 

Quick Seal  Quick Seal expert 10

µm

mm

BioP I

BioP II

2.0 mm I.D.

3

33 x 2.0

UP3BP1#3QS

UP3BP2#3QS

50 x 2.0

UP3BP1#5QS

UP3BP2#5QS

75 x 2.0

UP3BP1#7QS

UP3BP2#7QS

5

50 x 2.0

UP5BP1#5QS

UP5BP2#5QS

75 x 2.0

UP5BP1#7QS

UP5BP2#7QS

100 x 2.0

UP5BP1#10QS

UP5BP2#10QS

125 x 2.0

UP5BP1#12QS

UP5BP2#12QS

150 x 2.0

UP5BP1#15QS

UP5BP2#15QS

4.6 mm I.D.

3

33 x 4.6

UP3BP1-3QS

UP3BP2-3QS

50 x 4.6

UP3BP1-5QS

UP3BP2-5QS

75 x 4.6

UP3BP1-7QS

UP3BP2-7QS

5

50 x 4.6

UP5BP1-5QS

UP5BP2-5QS

75 x 4.6

UP5BP1-7QS

UP5BP2-7QS

100 x 4.6

UP5BP1-10QS

UP5BP2-10QS

125 x 4.6

UP5BP1-12QS

UP5BP2-12QS
-

150 x 4.6

UP5BP1-15QS

UP5BP2-15QS

µm

mm

BioP I

BioP II

2.0 mm I.D.

3

33 x 2.0

UP3BP1#3QK

UP3BP2#3QK

50 x 2.0

UP3BP1#5QK

UP3BP2#5QK

75 x 2.0

UP3BP1#7QK

UP3BP2#7QK

5

50 x 2.0

UP5BP1#5QK

UP5BP2#5QK

75 x 2.0

UP5BP1#7QK

UP5BP2#7QK

100 x 2.0

UP5BP1#10QK

UP5BP2#10QK

125 x 2.0

UP5BP1#12QK

UP5BP2#12QK

150 x 2.0

UP5BP1#15QK

UP5BP2#15QK

4.6 mm I.D.

3

33 x 4.6

UP3BP1-3QK

UP3BP2-3QK

50 x 4.6

UP3BP1-5QK

UP3BP2-5QK

75 x 4.6

UP3BP1-7QK

UP3BP2-7QK

5

50 x 4.6

UP5BP1-5QK

UP5BP2-5QK

75 x 4.6

UP5BP1-7QK

UP5BP2-7QK

100 x 4.6

UP5BP1-10QK

UP5BP2-10QK

125 x 4.6

UP5BP1-12QK

UP5BP2-12QK
-

150 x 4.6

UP5BP1-15QK

UP5BP2-15QK

 

On line extraction: Upti-Trap

 

The Upti-trap on line extraction system offers an optimal method for sample recovery. The systems requires two pumps, the first for extraction and the second for elution.

1- Extraction mode:

The mains compounds of interest are trapped while the residual sample is removed through the wash process.

 

2- Elution mode:

The mobile phase of second pump elute the principal compounds of interest. This compound is then analysed on the analytical column.

 

µm

mm

C18-HSC

C18-ODB

C18-HDO

C18-NEC

C8

C4

PH

CN

2.0 mm I.D.

3

20 x 2.0

UP3HSC#2

UP3ODB#2

UP3HDO#2

UP3NEC#3

UP3C8#2

UP3C4#2

UP3PH#3

UP3CN#2

5

20 x 2.0

UP5HSC#2

UP5ODB#2

UP5HDO#2

UP5NEC#3

UP5C8#2

UP5C4#2

UP5PH#3

UP5CN#2

4.0 mm I.D.

3

20 x 4.0

UP3HSC*2

UP3ODB*2

UP3HDO*2

UP3NEC*3

UP3C8*2

UP3C4*2

UP3PH*3

UP3CN*2

5

20 x 4.0

UP5HSC*2

UP5ODB-*2

UP5HDO*2

UP5NEC*3

UP5C8*2

UP5C4*2

UP5PH*3

UP5CN*2

 

Improve your productivity

 

A 10 way/2 position valve allow simultaneously the extraction of a sample while a second one is analysed on the analytical column.

 

mm

Phase

µm

Catalog #

15 x 4.0

C18 (end-capped)

50

U25750

RP.AQ (C18 100 % Hydrophile)

75

U25760

SCX (strong cation exchanger)

40

U25770

MM (mixed mode RP/SCX)

50

U25780

BCD (b-cyclodextrin)

40

U25790

 

 

 

 

 

-

Atoll TL (lipophile)

75

U25800

Atoll XC (Xtrem capacity)

30

U70480

Atoll XC (Xtrem capacity)

70

U25810

Atoll EV (mixed hydrophile/hydrophobe)

30

U70490

Atoll EV (mixed hydrophile/hydrophobe)

75

U25820

Atoll TH (Hydrophile)

75

U25830

mm

Phase

µm

Catalog #

15 x 2.1

C18 (end-capped)

50

U25840

RP.AQ (C18 100 % Hydrophile)

75

U25850

SCX (strong cation exchanger)

40

U25860

MM (mixed mode RP/SCX)

50

U25870

BCD (b-cyclodextrin)

40

U25880

 

 

 

 

 

-

Atoll TL (lipophile)

75

U25890

Atoll XC (Xtrem capacity)

30

U70500

Atoll XC (Xtrem capacity)

70

U25900

Atoll EV (mixed hydrophile/hydrophobe)

30

U70510

Atoll EV (mixed hydrophile/hydrophobe)

75

U25910

Atoll TH (Hydrophile)

75

U25920

 

Fine Chemicals

— 5000 Building Blocks for organic synthesis, parallel synthesis and Combinatorial Chemistry.

Your are using BORONIC ACIDS, BOC-FMOC-CBZ protected products and Heterocycles.

To get the catalog, please contact

interbulk@interchim.com

  Click here for the electronic catalog.

 

Direct injection of complex matrix

 

Interchim has designed Direct Injection Columns (DIC) for the quick analysis of drugs in biological fluids.

These columns are packed with 30 µm Atoll XC and AEV.

XC is very hydrophobic while AEV is both hydrophobic/hydropholic.

In case of multi drugs analysis, Interchim recommend either Uptisphere BioP I aor BioP II for the analytical reverse phase column.

Dimensions

Phase

P/N

50 x 1.0 mm

30 µm AEV

30AEVD5Q

30 µm XC

30XCD5Q

33 x 2.1 mm

30 µm AEV

30AEV#3Q

30 µm XC

30XC#3Q

20 x 2.1 mm

30 µm AEV

30AEV#2Q

30 µm XC

30XC#2Q

20 x 4.0 mm

30 µm AEV

30AEV*2Q

30 µm XC

30XC*2Q

 

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Tel. (33)(0)4 70 03 88 55  - Fax (33)(0)4 70 03 82 60 - Hot line: (33)(0)4 70 03 73 09

interchrom@interchim.com - www.interchim.com

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