Mya 4 Reaction Station

Mya 4 Reaction Station, one reaction station with limitless possibilities
New Model & Accessories

4 independent zones Magnetic and overhead stirring  -30 °C to +180 °C 2 ml to 400 ml vessels Software control

Key Features
A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry

Overview
A flexible tool for a wide range of applications, from discovery chemistry to process development
Flexible and versatile
4 different temperature zones, each with heating and active cooling Use one compact system for a range of experiments Precise temperature control Magnetic or optional overhead stirring Accepts a wide range of vessel sizes and styles Control your experiments and log results automatically Use Mya 4 with or without a chiller
		Applications
		Design of Experiment (DoE) Process development Scale up Route scouting Crystallisation studies Polymorph screening Biopharma research Lead optimisation Reaction optimisation Reagent, catalyst and solvent screening
Safer, cleaner, greener and more productive
Replace inefficient, messy and unsafe oil and ice baths Save space compared with separate reaction set-ups Software control improves safety, reduces manual errors, and allows 24/7 unattended chemistry, for improved productivity Create, repeat and share experiments and results with ease and accuracy Easily manage complex multi-step and multi-device experiments Integrates 3rd party devices such as pumps, balances and pH sensors etc. TFE lids to hold 3rd party process analytical technology (PAT) such as Blaze Metrics.

Mya 4 - Details
Precise temperature control of four independent zones with magnetic or overhead stirring
		4 reaction zones
		Use 1, 2, 3 or 4 zones Operate zones in parallel or individually by multiple users Compact footprint 600 (W) x 360 (D) x 370 (H) mm
		Precise temperature control
		Temperature range from -30 °C to +180 °C (block temperature) Providing a solution temperature of at least -20 °C to 150 °C Up to 200 °C difference between adjacent positions Control the temperature of each zone independently Choose to control by block or solution temperature Pt100 temperature probes available in stainless steel or PTFE encapsulated
		Use Mya 4 with or without a chiller
		Mya 4 uses powerful Peltier technology to provide rapid cooling to -30 °C Peltier cells require tap or chilled water to dissipate heat
		Peltier cooling source	Tap water at 15 °C	Chilled water at 5 °C
		Minimum block temperature	-25 °C	-30 °C
		Minimum solution temperature	-20 °C	-25 °C
		Magnetic or optional overhead stirring
		Integrated magnetic stirring - from 100 to 1000 rpm Optional overhead stirring - from 100 to 1000 rpm Control the stirring speed of each position independently Use magnetic or overhead stirring in adjacent zones
		Software control and data logging
		Choice of Touch-screen Control Pad and PC Control Software Run experiments in manual or profile mode Easily repeat profiles Export CSV data

Glassware and accessories
Choose from a wide selection of vials, tubes, round bottom flasks and process vessels, from 2 ml to 400 ml
Wide selection of vessel styles and volumes
Process reaction vessels: With straight sides and dished base to mimic jacketed reactors 50 ml, 100 ml, 150 ml, 250 ml and 400 ml Side arm option Baffled vessel options
Round bottom flasks from the Carousel 6 Plus range: 25 ml, 50 ml, 100 ml and 250 ml One or two side arm options Standard and wide neck options Baffled vessel options
Vials and tubes from 2 ml to 50 ml: 12 mm, 16 mm, 17 mm, 17 mm tapered, 24 mm, 1 inch and 28 mm diameters Radleys Carousel 12 Plus reaction tubes
Aluminium Inserts
Removable anodised aluminium inserts for different size vessels
Multi-neck lids
For wide neck round bottom flasks and process vessels
PTFE lids 5 or 6-neck For improved durability and safety Stronger to support heavier probes/accessories 6-neck PTFE Blaze probe lid
Glass lids 3 or 5-neck 3.3 Borosilicate glass
Accessory glassware
A wide range of dedicated glass accessories including:
Condensers Dropping funnels Solid addition funnels Stoppers

Head options - refluxing & glassware support
Choose from three different Mya 4 heads to suit your chemistry needs. Easy to set up and no tools required.
		Manifold Head
		Provides cooling water to glass condensers and distributes inert gas
		Required when using multi-neck lids All the water connections have shut-off valves - no mess Note: Glassware with reflux tubes can be used but not for refluxing
		Reflux Head
		Cools reflux tubes and distributes inert gas
		Can be used with reflux tubes (or wide neck reflux tubes) and short tubes/vials Note: Can be used with overhead stirrers
		Support Head
		Choose the Support Head if you want to use different glassware and accessories such as:
		Findenser and Findenser Mini Traditional glass condensers Non-standard flasks and tubes Soxhlet extraction glassware Probes and sensors Use with StarFish gas and water manifold

Customer testimonials
Accurate temperature control achieving big results, on a small scale
Mya 4 applications which require accurate temperature control:
Exothermic reactions - which require active cooling Study of parameters other than temperature - which require reliable and reproducible temperatures Working with temperature-sensitive materials (e.g. biomolecules) - which require tightly controlled temperatures Experiments requiring slow cooling or heating ramps
Johnson Matthey - Macfarlan Smith, API manufacturer
Study of key processing parameters other than temperature
´The precise temperature control provided by the Mya 4 has been essential to understanding key processing parameters of temperature sensitive experiments. It has allowed us to improve our understanding of current manufacturing processes." " Without accuracy of temperature, you cannot conduct a successful design of experiment (DoE) exercise." Dr Timothy Davies, Senior Development Chemist
Opioid manufacturer
Carefully controlled cooling ramps for crystallisation optimisation
"Prior to acquiring Mya 4, we used stirring hotplates and liquid cooling baths (dry ice/acetone) when needed. The set up and tinkering using this regime was completely obviated with Mya 4, which is basically a walk up reaction workstation." "We do a lot of reaction optimisation work (different catalyst loads, different temperatures, etc.) and recently had to do a crystallisation optimisation that required carefully controlled cooling ramps – all of this was a breeze with Mya 4 and made our research progress much quicker." Senior Process Development Chemist
Purolite Life Sciences, Resin manufacturer
Temperature-sensitive materials and exothermic reactions
´Mya 4 fulfils the need of a multipurpose small-scale reactor system that is not overspecified. The fact that the unit is so versatile is a strong advantage.´ ´On previous systems I have looked at, flask sizes were limited to only one or two options. I would have loved a Mya 4, two years ago so I could have used it as the workhorse for most of the project.´ Dr Patrick Gilbert, R&D Manager

Mya 4 Control Pad
Unattended chemistry 24/7 with software control for improved productivity, safety and reduced manual errors
Touch-screen Control Pad
Supplied as standard with Mya 4 Set automated profiles or use manual control Intuitive and easy to use Compact footprint with large 10" display
Control Options
The touch-screen Control Pad requires minimal training. It will control and log heating/cooling and stirring for all four zones independently. Repeating experiments and exporting data is a breeze.
Upgrade to the Mya 4 PC Control Software if you also want to:
Integrate 3rd party devices e.g. pumps and pH meters Create profile experiments with any number of steps Increase safety by using warnings, safe states and shut down settings Create a comprehensive report in a few clicks at the end of your experiment

Features	Control Pad	PC Software
Intuitive and easy to use touch-screen control	✔	✖
Compact footprint - fumehood compatible	✔	✖
Maximum 10 steps of 16 hours each	✔	✖
Multi-user - independently run experiment in 4 zones	✔	✖
Control and log the temperature and stirring of each zone independently	✔	✔
Set safety limits	✔	✔
Export experimental profiles and results in CSV via USB memory stick	✔	✔
Adjust parameters manually - using manual/direct mode	✔	✔
Create multi-step recipes - using profile/schedule mode	✔	✔
Flexibility to make and track on-the-fly adjustments to your experiment	✔	✔
Automatically log all data	✔	✔
Share experimental results and recipes with other users	✔	✔
View real-time graphs	✔	✔
Control and log up to 16 x 3rd party devices on one screen	✖	✔
Create complex experiments with any number of steps	✖	✔
Interlink devices and set feedback/control loops and end point conditions	✖	✔
Report Wizard creates detailed reports in RTF or export results in CSV	✖	✔
Log comments	✖	✔
Runs on a Windows laptop	✖	✔

Mya 4 PC Control Software
Advanced software control with added safety features, 3rd party device integration and reporting
		Mya 4 Control Software
		Integrate and control 3rd party devices Create complex experiments with any number of steps Report Wizard creates reports in rich text format or export results in CSV

Mya 4 PC Control Software will control and log 3rd party devices		Control 3rd party devices
		Mya 4 Control Software includes a library of pre-configured driver files allowing easy integration with a range of 3rd party devices.
		Data hub
		Using the Data Hub, Mya 4 Control Software can connect to, control and log data from multiple devices with an RS232 serial interface.
How to configure your Mya 4 Reaction Station
Select the components you need to suit your chemistry Our experts can advise you on the best options for your application

1	Stirring options Select stirrer bars for magnetic stirring and/or Mya compact stirrers and stirrer shafts for overhead stirring.
2	Head options Select a Manifold, Reflux or Support head.
3	Lids or reflux tubes Glass or PTFE multi-neck lids. Standard or wide-neck reflux tubes.
4	Vessel styles & volumes Select vessels: tubes, vials, round bottom flasks and process vessels from 2 ml to 400 ml.
5	Aluminium inserts Select the appropriate insert for each vessel size.
6	Select accessories Temperature probes, funnels, condensers etc.
7	Control options Select the optional Mya 4 PC Control Software, Data Hub and any 3rd party devices.

Mix & Match
A flexible reaction station with a wide range of options and accessories to fit your needs
		Reflux Head
		Manifold Head
		Applications
		Design of Experiment (DoE) Process development Scale up Route scouting Crystallisation studies Polymorph screening Biopharma research Lead optimisation Reaction optimisation Reagent, catalyst and solvent screening
Discover the system in video