ArrheniusOne™
for continuous-flow, microwave-assisted organic synthesis with FlowSyn™

Cut time, cost and environmental impact of drug discovery experiments Ensure safe, trouble-free synthesis and scale-up Develop more new candidate drugs per project

ArrheniusOne
is an innovative state-of-the-art microwave generator and applicator for continuous-flow, microwaveassisted
organic synthesis (CF-MAOS) in drug development experiments.
Combining continuous flow with microwave heating can significantly reduce total process times during the development of pharmaceutical compounds. The rapid, uniform heating provided by the ArrheniusOne delivers 10 to 1000 times faster
reaction rates within minutes. Continuous flow allows more compound to be produced safely while consuming less energy and producing less waste. Reaction conditions are quickly optimised, thereby eliminating the need for re-optimisation during scale-up and so saving time downstream.
Developed by microwave technology specialist WaveCraft of Sweden and marketed jointly by Uniqsis and WaveCraft, the
ArrheniusOne
is designed to operate with two- or four-channel FlowSyn
continuous flow reactor systems from Uniqsis.
The two products combine to offer a unique solution for rapid optimisation and scale-up of compound production to
dramatically increase productivity and efficiency, while reducing energy consumption and environmental impact.
Typical CF-MAOS applications include catalysed styrene synthesis, catalysed Suzuki−Miyaura coupling, Fischer indole
synthesis, Claisen rearrangement and many others.

Improved efficiency - reactions rates accelerated by a factor of 10 to 1000 by microwave heating.
Faster work-up of final product - controllable microwave power and frequency during heating allow for rapid dynamic optimisation of reaction conditions
Immediate scale-up - large reactor capacity and 4-channel capability allow for rapid scale-up to multi-kg quantities
Time saving - time to produce and scale up compounds reduced by a factor of 4 to 10
Reduced environmental impact - combination of CF-MAOS and continuous flow uses less energy and produces less waste

 CF-MAOS with ArrheniusOne™

The ArrheniusOne
microwave generator utilises a semi-conductor design to enable dynamic optimisation of process conditions by changing power and frequency during heating. Optimisation is controlled by an algorithm in the ArrheniusOne
control software. Microwaves are transmitted to the ArrheniusOne
applicator via a coaxial waveguide. The applicator provides a fundamentally new concept for microwave heating. This non-resonant microwave applicator generates a concentrated, homogenous axial field to provide even heating within a flow reactor.

	Uniform heating: the innovative Arrhenius microwave applicator prevents hot and cold spots