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INTERFINE CHEMICALS > Synthesis Systems > Automated Reaction Station

Mya 4 Reaction Station, one reaction station with limitless possibilities


 

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Key Features
 

   
A 4-zone reaction station offering safe and precise heating, active cooling, software control and data-logging for 24/7 unattended chemistry
     
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Overview
 

   
A flexible tool for a wide range of applications, from discovery chemistry to process development
     
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Flexible and versatile
 

   
  • 4 different temperature zones, each with heating and active cooling
  • Use one compact system for a range of experiments
  • Precise temperature control
  • Magnetic or optional overhead stirring
  • Accepts a wide range of vessel sizes and styles
  • Control your experiments and log results automatically
  • Use Mya 4 with or without a chiller
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Applications
 

 
  • Single or parallel synthesis
  • Design of Experiment (DoE)
  • Process development
  • Scale up
  • Route scouting
  • Crystallisation studies
  • Polymorph screening
  • Lead optimisation
  • Reaction optimisation
  • Reagent, catalyst and solvent screening
     

Safer, cleaner, greener and more productive
 

   
  • Replace inefficient, messy and unsafe oil and ice baths
  • Save space compared with separate reaction set-ups
  • Software control improves safety, reduces manual errors, and allows 24/7 unattended chemistry, for improved productivity
  • Create, repeat and share experiments and results with ease and accuracy
  • Easily manage complex multi-step and multi-device experiments
  • Integrate 3rd party devices such as pumps, balances and pH sensors etc.
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Mya 4 - Details
 

Precise temperature control of four independent zones with magnetic or overhead stirring
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4 reaction zones
 

 
  • Use 1, 2, 3 or 4 zones
  • Operate zones in parallel or individually by multiple users
  • Compact footprint 600 (W) x 360 (D) x 370 (H) mm
   
 

Precise temperature control

 
Temperature range from -30 °C to +180 °C (block temperature)
  • Providing a solution temperature of at least -20 °C to 150 °C
  • Up to 200 °C difference between adjacent positions
  • Control the temperature of each zone independently
  • Choose to control by block or solution temperature
  • Pt100 temperature probes available in stainless steel or PTFE coated
   
 

Use Mya 4 with or without a chiller

 
Mya 4 uses powerful Peltier technology to provide rapid cooling to -30 °C
  • Peltier cells require tap or chilled water to dissipate heat
   
  Peltier cooling source Tap water at 15 °C Chilled water at 5 °C
  Minimum block temperature -25 °C -30 °C
  Minimum solution temperature -20 °C -25 °C
   
 

Magnetic or optional overhead stirring
 

 
  • Integrated magnetic stirring - from 100 to 1000 rpm
  • Optional overhead stirring - from 100 to 1000 rpm
  • Control the stirring speed of each position independently
  • Use magnetic or overhead stirring in adjacent zones
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Software control and data logging

 
Choice of Touch-screen Control Pad and PC Control Software
  • Run experiments in manual or profile mode
  • Easily repeat profiles
  • Export CSV data
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Glassware and accessories
 

   
Choose from a wide selection of vials, tubes, round bottom flasks and process vessels, from 2 ml to 400 ml
     

Wide selection of vessel styles and volumes

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Vials and tubes from 2 ml to 50 ml:
  • 12 mm, 16 mm, 17 mm, 17 mm tapered, 24 mm, 1 inch and 28 mm diameters
  • Radleys Carousel 12 Plus reaction tubes
 
   
Round bottom flasks from the Carousel 6 Plus range:
  • 25 ml, 50 ml, 100 ml and 250 ml
  • One or two side arm options
  • Standard and wide neck options
  • Baffled vessel options
 
   
Process reaction vessels:
  • With straight sides and dished base to mimic jacketed reactors
  • 50 ml, 100 ml, 150 ml, 250 ml and 400 ml
  • Side arm option
  • Baffled vessel options
 
   

Aluminium Inserts

 
Removable anodised aluminium inserts for different size vessels
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Multi-neck lids

 
For wide neck round bottom flasks and process vessels  
   
Glass lids
  • 3 or 5-neck
  • 3.3 Borosilicate glass
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PTFE lids
  • 5-neck
  • For improved durability and safety
  • Stronger to support heavier probes/accessories
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Accessory glassware

 
A wide range of dedicated glass accessories including:

 
  • Condensers
  • Dropping funnels
  • Solid addition funnels
  • Stoppers
 
     

Head options - refluxing & glassware support
 

Choose from three different Mya 4 heads to suit your chemistry needs. Easy to set up and no tools required.
       
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Manifold Head

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Provides cooling water to glass condensers and distributes inert gas
 
 
  • Required when using multi-neck lids
  • All the water connections have shut-off valves - no mess
  • Note: Glassware with reflux tubes can be used but not for refluxing
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Reflux Head

 
Cools reflux tubes and distributes inert gas
 
  • Can be used with reflux tubes (or wide neck reflux tubes) and short tubes/vials
  • Note: Can be used with overhead stirrers
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Support Head

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Choose the Support Head if you want to use different glassware and accessories such as:
 
  • Findenser and Findenser Mini
  • Traditional glass condensers
  • Non-standard flasks and tubes
  • Soxhlet extraction glassware
  • Probes and sensors
  • Use with StarFish gas and water manifold
       

Customer testimonials
 

   
Accurate temperature control achieving big results, on a small scale

   
     

Mya 4 applications which require accurate temperature control:
 

   
  • Exothermic reactions - which require active cooling
  • Study of parameters other than temperature - which require reliable and reproducible temperatures
  • Working with temperature-sensitive materials (e.g. biomolecules) - which require tightly controlled temperatures
  • Experiments requiring slow cooling or heating ramps
   
     

Johnson Matthey - Macfarlan Smith, API manufacturer

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Study of key processing parameters other than temperature
 
 
´The precise temperature control provided by the Mya 4 has been essential to understanding key processing parameters of temperature sensitive experiments. It has allowed us to improve our understanding of current manufacturing processes.´ ´Without accuracy of temperature, you cannot conduct a successful design of experiment (DoE) exercise.´
Dr Timothy Davies, Senior Development Chemist
 
     

Opioid manufacturer

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Carefully controlled cooling ramps for crystallisation optimisation
 
 
´Prior to acquiring Mya 4, we used stirring hotplates and liquid cooling baths (dry ice/acetone) when needed. The set up and tinkering using this regime was completely obviated with Mya 4, which is basically a walk up reaction workstation.´
´We do a lot of reaction optimisation work (different catalyst loads, different temperatures, etc.) and recently had to do a crystallisation optimisation that required carefully controlled cooling ramps – all of this was a breeze with Mya 4 and made our research progress much quicker.´

Senior Process Development Chemist
 
     

Purolite Life Sciences, Resin manufacturer

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Temperature-sensitive materials and exothermic reactions
 
 
´Mya 4 fulfils the need of a multipurpose small-scale reactor system that is not overspecified. The fact that the unit is so versatile is a strong advantage.´
´On previous systems I have looked at, flask sizes were limited to only one or two options.
I would have loved a Mya 4, two years ago so I could have used it as the workhorse for most of the project.´

Dr Patrick Gilbert, R&D Manager
 
     
     

Mya 4 Control Pad
 

   
Unattended chemistry 24/7 with software control for improved productivity, safety and reduced manual errors

     

Touch-screen Control Pad

   
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  • Supplied as standard with Mya 4
  • Set automated profiles or use manual control
  • Intuitive and easy to use
  • Compact footprint
 
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Control Options

The touch-screen Control Pad requires minimal training. It will control and log heating/cooling and stirring for all four zones independently. Repeating experiments and exporting data is a breeze.
     

Upgrade to the Mya 4 PC Control Software if you also want to:
 

  • Integrate 3rd party devices e.g. pumps and pH meters
  • Create profile experiments with any number of steps
  • Increase safety by using warnings, safe states and shut down settings
  • Create a comprehensive report in a few clicks at the end of your experiment
     
Features Control Pad PC Software
Intuitive and easy to use touch-screen control
Compact footprint - fumehood compatible
Maximum 10 steps of 16 hours each
Multi-user - independently run experiment in 4 zones
Control and log the temperature and stirring of each zone independently
Set safety limits
Export experimental profiles and results in CSV via USB memory stick
Adjust parameters manually - using manual/direct mode
Create multi-step recipes - using profile/schedule mode
Flexibility to make and track on-the-fly adjustments to your experiment
Automatically log all data
Share experimental results and recipes with other users
View real-time graphs
Control and log up to 16 x 3rd party devices on one screen
Create complex experiments with any number of steps
Interlink devices and set feedback/control loops and end point conditions
Report Wizard creates detailed reports in RTF or export results in CSV
Log comments
Runs on a Windows laptop
     

Mya 4 PC Control Software
 

   
Advanced software control with added safety features, 3rd party device integration and reporting
     
   

Mya 4 Control Software

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  • Integrate and control 3rd party devices
  • Create complex experiments with any number of steps
  • Report Wizard creates reports in rich text format or export results in CSV
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Mya 4 PC Control Software will control and log 3rd party devices

 

Control 3rd party devices

Mya4_Reaction_Station29_Radleys_Interchim_0520   Mya 4 Control Software includes a library of pre-configured driver files allowing easy integration with a range of 3rd party devices.

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Data hub

  Using the Data Hub, Mya 4 Control Software can connect to, control and log data from multiple devices with an RS232 serial interface.
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How to configure your Mya 4 Reaction Station
 

   
Select the components you need to suit your chemistry Our experts can advise you on the best options for your application
     
1

Stirring options

Select stirrer bars for magnetic stirring and/or Mya compact stirrers and stirrer shafts for overhead stirring.
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2

Head options

Select a Manifold, Reflux or Support head.
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3

Lids or reflux tubes

Glass or PTFE multi-neck lids. Standard or wide-neck reflux tubes.
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4

Vessel styles & volumes

Select vessels: tubes, vials, round bottom flasks and process vessels from 2 ml to 400 ml.
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5

Aluminium inserts

Select the appropriate insert for each vessel size.

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6

Select accessories

Temperature probes, funnels, condensers etc.
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7

Control options

Select the optional Mya 4 PC Control Software, Data Hub and any 3rd party devices.
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Mix & Match
 

   
A flexible reaction station with a wide range of options and accessories to fit your needs
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Reflux Head

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Manifold Head

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Applications

 
  • Single or parallel synthesis
  • Design of Experiment (DoE)
  • Process development
  • Scale up
  • Route scouting
  • Crystallisation studies
  • Polymorph screening
  • Lead optimisation
  • Reaction optimisation
  • Reagent, catalyst and
    solvent screening
  Products highlight
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